Ivetra 250 FC tab/Ivetra 500 FC tab/Ivetra 1000 FC tab/Ivetra-100 oral soln Monotherapy Adult & adolescent from 16 yr Initially 250 mg bid, increased to 500 mg bid after 2 wk. Can be further increased by 250 mg bid every 2 wk depending on clinical response. Max: 1,500 mg bid.
Add-on therapy Adult (>18 yr) & adolescent (12-17 yr) weighing ≥50 kg Initially 500 mg bid, started on the 1st day of treatment. Can be increased up to 1,500 mg bid depending on clinical response & tolerability. Dose changes can be made in 500 mg bid increases or decreases every 2-4 wk.
Adolescent (12-17 yr) & childn (4-11 yr) <50 kg Initially 10 mg/kg bid. Can be increased up to 30 mg/kg bid depending on clinical response & tolerability. Dose changes should not exceed increases or decreases of 10 mg/kg bid every 2 wk.
Adolescent, childn, & infant from 6 mth weighing from 50 kg Initially 500 mg bid, max: 1,500 mg bid;
25 kg Initially 250 mg bid, max: 750 mg bid;
20 kg Initially 200 mg (2 mL) bid, max: 600 mg (6 mL) bid;
15 kg Initially 150 mg (1.5 mL) bid, max: 450 mg (4.5 mL) bid;
10 kg Initially 100 mg (1 mL) bid, max: 300 mg (3 mL) bid;
6 kg Initially 60 mg (0.6 mL) bid, max: 180 mg (1.8 mL) bid.
Infant from 1-< 6 mth Initially 7 mg/kg bid. Can be increased up to 21 mg/kg bid depending on clinical response & tolerability. Dose changes should not exceed increases or decreases of 7 mg/kg bid every 2 wk.
Adult & adolescent >50 kg Renal impairment CrCl >80 mL/min/1.73 m2 500-1,500 mg bid,
50-79 mL/min/1.73 m2 500-1,000 mg bid,
30-49 mL/min/1.73 m2 250-750 mg bid,
<30 mL/min/1.73 m2 250-500 mg bid.
ESRD patient undergoing dialysis 500-1,000 mg once daily. Loading dose: 750 mg on the 1st day of treatment. Supplemental dose: 250-500 mg following dialysis.
Adolescent, childn <50 kg, & infant 6-23 mth Renal impairment CrCl >80 mL/min/1.73 m2 10-30 mg/kg bid,
50-79 mL/min/1.73 m2 10-20 mg/kg bid,
30-49 mL/min/1.73 m2 5-15 mg/kg bid,
<30 mL/min/1.73 m2 5-10 mg/kg bid.
ESRD patient undergoing dialysis 10-20 mg/kg once daily. Loading dose: 15 mg/kg on the 1st day of treatment. Supplemental dose: 5-10 mg/kg following dialysis.
Ivetra-100 oral soln Add-on therapy Adolescent (12-17 yr), childn (2-11 yr), & infant (from 6-23 mth) weighing <50 kg Initially 10 mg/kg bid. Can be increased up to 30 mg/kg bid depending on clinical response & tolerability. Dose changes should not exceed increases or decreases of 10 mg/kg bid every 2 wk.
Infant <6 mth weighing 7 kg 49 mg (0.5 mL) bid, max: 147 mg (1.5 mL) bid;
5 kg 35 mg (0.35 mL) bid, max: 105 mg (1.05 mL) bid;
4 kg 28 mg (0.3 mL) bid, max: 84 mg (0.85 mL) bid.
Ivetra IV soln for inj Partial onset seizures Adult ≥16 yr 1,000 mg/day in 2 divided dosing (500 mg bid). May give additional dosing increments of 1,000 mg/day every 2 wk. Max: 3,000 mg daily.
Childn 4-<16 yr 20 mg/kg in 2 divided doses (10 mg/kg bid). Increase every 2 wk by increments of 20 mg/kg to the recommended daily dose of 60 mg/kg (30 mg/kg bid). May reduce if patient cannot tolerate 60 mg/kg daily dose. Max: 3,000 mg daily.
6 mth-<4 yr 20 mg/kg in 2 divided doses (10 mg/kg bid). Increase every 2 wk by increments of 20 mg/kg to recommended daily dose of 50 mg/kg (25 mg/kg bid). May reduce dose if patient cannot tolerate 50 mg/kg daily.
1 mth-<6 mth 14 mg/kg in 2 divided dose (7 mg/kg bid). Increase every 2 wk by increments of 14 mg/kg to recommended daily dose of 42 mg/kg (21 mg/kg bid).
Myoclonic seizures in patient w/ juvenile myoclonic epilepsy 1,000 mg/day in 2 divided doses (500 mg bid). Increase every 2 wk by 1,000 mg/day to recommended daily dose of 3,000 mg daily.
Primary generalized tonic-clonic seizures Adult ≥16 yr 1,000 mg/day in 2 divided doses (500 mg bid). Increase every 2 wk by 1,000 mg/day to recommended daily dose of 3,000 mg daily.
Childn 6-<16 yr 20 mg/kg in 2 divided dose (10 mg/kg bid). Increase every 2 wk by increments of 20 mg/kg (10 mg/kg bid) to the recommended daily dose of 60 mg/kg (30 mg/kg bid).
Adult Renal impairment CrCl >80 mL/min/1.73 m2 500-1,500 mg every 12 hr,
50-80 mL/min/1.73 m2 500-1,000 mg every 12 hr,
30-50 mL/min/1.73 m2 250-750 mg every 12 hr,
<30 mL/min/1.73 m2 250-500 mg every 12 hr.
ESRD patient undergoing dialysis 500-1,000 mg every 24 hr. Supplemental dose: 250-500 mg following dialysis.